Image of thirty-three diphenhydramine capsules, measuring out to be 825 milligrams.

Diphenhydramine (known scientifically as diphenhydramine hydrochloride), whose common brand names include Benadryl, Nytol, and Dimedrol, is a sedative antihistamine drug that, when taken in dosages far beyond medically advised, produces auditory and visual true hallucinations that are often indistinguishable from reality.

When taken in typical non-recreational doses, it acts as an antiemetic, antihistamine, hypnotic, sedative, anxiolytic, and mild cough medicine. In over-the-counter doses, the chemical is actually particularly safe, but has a range of side effects including auditory disturbances, dryness of mucous membranes (including the mouth, nose, and eyes), drowsiness or restlessness, excitability, and decreased libido, among other effects.

Method of UseEdit

Diphenhydramine is primarily ingested orally through capsules or chewable pills, though there have been reports of inhaling the vapors (which is feasible but definitely not advised due to harm on the lungs) and insufflating the crystals to produce the desired delirium.

Recreational DosageEdit

Typical medically advised doses fall in between twenty-five and fifty milligrams. At this level, the chemical acts as a mild hypnotic and allergy-reliever, as well as an antiemetic with antivertigo properties.

Recreational doses are anywhere from one hundred to seven hundred milligrams. With any dose above the latter, the chances of a life-threatening condition greatly increase. These conditions include heart attacks, seizures, and comas, among other problems. There have been many reports of people taking vastly greater amounts than seven hundred, however; most live through the experience but are often taken to the hospital where they encounter an even more frightening environment.

The ExperienceEdit

From what reports conclude, the effects of diphenhydramine start very slowly, usually peaking around two and half hours after ingestion. Heaviness is often felt, as well as feelings of weightlessness, euphoria or dysphoria, increased awareness of sounds, increased appreciation of music, visual and auditory true hallucinations, and unusual speech. The more heavy effects are generally the effects sought after by the select few who decide to take this substance. Users often report having conversations with entirely realistic beings and relatives or friends only to realize that they were not even there. Objects often change textures (wood to rock, skin to water, carpet to gravel, etc.) during the experience. People commonly state that most experiences consist of seeing things that aren't there, and even not seeing things that are there, as well as completely tasks only to realize that they hadn't even started them.


Diphenhydramine is considered to be a legal over-the-counter medicine that does not require a prescription in almost all countries, except for the Republic of Zambia, where it is heavily regulated.

Danger RatingEdit

Physical -- 4

Psychological -- 4

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